Van de Ven Double Ends The Toffees' Run at Brand New Home Ground
The Dutch defender became the initial defender to score twice in a English top-flight match for Spurs since the Belgian defender in March 2013.
At a glance
Micky Van de Ven heads home twice in opening period
Everton's defender has equalizer disallowed after VAR review
Senegalese midfielder nets third in 89th minute
This loss is the Merseyside club's first at their new ground
The Tottenham defender scored twice as Spurs extended their unbeaten run on the road in the top division and delivered the Toffees their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain the Dutchman pounced twice from corners in the first half to place their strong form at risk, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had equalized the tally a short while after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a succession of excellent stops to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the VAR stepped in, advising Craig Pawson to check the score on the pitchside monitor and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates the manager's team into third place in the Premier League, a handful of points off north London rivals and table-toppers the Gunners.
Everton stay in 14th position and are half a dozen points ahead of the relegation zone.
Tottenham analysis: The defender excels in role at each end of the field
Following a uninspiring midweek display in the Champions League against the French side, where they mustered a only two shots on goal, Frank chose the French striker up front instead of ex-Everton forward Richarlison.
The summer signing was failed to make much of an impact before being substituted for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a cleverly executed corner routine, with the midfielder directing the ball toward the face of goal for an unmarked the defender to score.
And the captain - stepping up as captain in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he outjumped the England keeper to head home.
Van de Ven was just as outstanding in defensive duties, combining well with Kevin Danso as the duo dealt excellently with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton lacking striker's instinct
The club's new home had been a happy hunting ground, but it appears the freshness may have faded slightly and supporters flocked to the exits after Sarr's third for Spurs.
The end in Everton's winning streak at home will not be a major concern for David Moyes, but their striker situation are.
The forward and the other striker - the Everton's pair of recognised strikers - had scored just one league goal between them before the weekend's match.
And they were unable to add to that poor record on a wet and gloomy evening on Merseyside.
The striker's performance was summed up when he chose to bicycle-kick a golden opportunity from close range, despite having room and opportunity to reposition for a simpler attempt that would have challenged Vicario.
Barry, as well, failed to make an impact after coming on for Beto in the 65th minute.
It wasn't for a lack of chance. Most of Everton's attacks came through the winger and the forward, who tirelessly whipped threatening crosses into the Spurs box.
What next for both teams?
Everton: The team travel to Sunderland in the top flight on early November at 20:00 GMT.
Spurs: The London club go to Newcastle's ground on late October for their fourth-round Carabao Cup match against Newcastle.